CHEM 222 Lecture Notes - Lecture 6: Electrophilic Aromatic Substitution, Reaction Coordinate, Alkene

• School: McGill University
• Department: Chemistry
• Course: CHEM 222
• Professor: Laura Pavelka

Document Summary

Know the reactions covered for the oxidation of alkenes, oxidation of alcohols, substitutions, and electrophilic aromatic substitution; i. e. provide starting materials, reagents, or products. Propose reasonable mechanisms for a given reaction (synthesis or transformation using org1 mechanisms) Utilize reactions in multi-step syntheses (will build as we learn more types of reactions) Problem 4. 1: mechanisms: add the curved arrows to complete each transformation below (extra intermediates may need to be drawn), find the error in the mechanism below. Problem 4. 2: reactive coordinate diagrams and energy: draw a mechanism and reaction coordinate diagram to describe the reaction below, explain why the major product is favoured. Problem 4. 3: reactivity: fill in the missing pieces to complete the transformations below. Problem 4. 4: multi-step synthesis: predict the products for the multi-step synthesis below, propose a synthesis to accomplish each of the transformations below. An alcohol (a) was treated with pcc in ch2cl2 to yield compound b.