BIOL 201 Lecture Notes - Lecture 27: Dynein, Melanocyte, Dynactin
23 Apr 2016
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Document Summary
Certain cells need to orient themselves towards a chemotactic gradient. Activated cdc42 (gtpase) activates rac which activates arp2/3 copmlex favouring branched formation of actin. Activating rac activates rho which favours stress fibers and polymerization of long actin filaments. Cytokinesis: final stages of cell division, chromosomes in two daughter cells, in middle bisect what makes up spindle and give rise to 2 daughter cells. 3 cytoskeletal systems are coordinated: microtubules for migration, myosins transport vesicles, microtubules organize contractile ring. Rho family gtpases are activated by extracellular signals by bringing in gef into proximity with rho in membrane: small gtpase bound to gdp is inactive, due to gef though you can replace with. Gtp making it active rho: gap protein brings it back to inactive form. Some microtubules can penetrate into leading edge pioneer microtubules. Growing microtubules activate rac: can see with western blots for antibodies for gtp bound rac, remove drugs that normally depolymerize microtubules we activate rac because.
