BIOL 201 Lecture 28: BIOL 201 lecture 28
11 Apr 2018
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+ cytokinesis: reformation of interphase microtubule array, cleavage furrow. Basic steps: cells of the same size, offset if you want asymmetric cells ) Kinesins and dynein"s are the engines of mitosis. Kinesin is the motor protein which walks to the + end of microtubules. Kinesin 5"s are tetrameric kinesins that are in charge of separating the centrosomes: they are homo-tetramers, they slide antiparallel microtubules apart. View the kinesin as immobile and the microtubules as mobile. The kinesins head domains wants to walk towards the + end of both microtubules. Since we are in the frame of reference of the kinesin, we observe the kinesin pushing the two microtubules apart they are, after all, oriented in different directions: this can be reconstructed in the lab. Knock-out kinesin-5 and you get a monopolar phenotype because centrosomes don"t segregate. Putting the spindles at the right location: studying asymmetric cell divisions. Examples of asymmetric divisions: first cell stage of c. elegans divides asymmetrically.
