BIOL 200 Lecture Notes - Lecture 16: Nucleated Red Blood Cell, Telomerase Reverse Transcriptase, Nucleoprotein
Document Summary
Many polypeptides are composites of different combinations of domains: (cid:120) shuffling in domains occurs at the protein level instead of the dna level (cid:120) thought to be mediated by transposons. If new exon is acquired, new coding domain is acquired (cid:120) (cid:120) coding domains could be shuffled in by shuffling of exons. Ltr retrotransposons and lines have their own protein- coding capacity. If these elements also insert near genes, they can affect (cid:120) (cid:120) nearby gene expression. (cid:120) e. g. insecticide resistance: as we introduce new insecticides there is more insecticide resistance, resistance was somehow coupled with p450. In one particular p450 gene, there was an ltr retrotransposon gene this element jumped in with. 12 its resistance line and conferred ddt resistance by overexpression. Over evolutionary time, selection will only be on the maintenance of the crm and not the rest of transposon: (cid:120) the rest of the elements would degrade over time.
