BIOL 200 Lecture Notes - Lecture 9: Antibody, Rag1, Exon Shuffling
23 Jan 2018
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Document Summary
October 2nd: gene duplication, exon shuffling, cis-regulatory module diversification, transduction and transduplication, domesticated transposons. Negative correlation between transposon mobility and fitness. Over 100 retrotransposon insertions have been associated with human diseases. No: transposon allows us to associate the genotype and phenotype. Ex: p-element insertion into drosophila s6 kinase gene (responsible for body size) makes it smaller. Insertion of tos17 into rice gene pish (fungal resistance) increases susceptibility to fungal infection. You"re adding a domain or protein to a protein complex: can be mediated by retrotransposition. In gene 1 there is a line element. Here, ac, mudra and tnp2 are dna transposases commonly found in eukaryotes. Mule stands for mutator-like elements" and cacta is just the sequence of the first five base- pairs. They have their own promoters and cis-regulatory modules (crm): lines and sines also have cis-reg modules, crms can affect close-by genes, ex: Lines of drisophylla resistant to ddt (gene p450 one of these was evolved to resist.
