KINS 1100 Lecture Notes - Lecture 8: Globin, Monocyte, Atherosclerosis
Document Summary
White blood cells & platelets (1% of formed elements) Anemia : blood"s oxygen-carrying capacity is too low to support normal metabolism. Common ways : epo, synthetic o 2 carriers, and blood transfusions. Adverse effects : increased risk of cv diseases & blood contamination. Leukemia : red bone marrow produces cancerous wbcs, which proliferate out of control and remain unspecialized. Essential for homeostasis (i. e. stops blood loss from ruptured vessels (clots)) Too many platelets may spontaneously start clotting on their own. Atherosclerosis : build up of plaque in arteries (disease) Can take decades for the build up to be abnormal. At rest: the largest portion of blood is in systemic veins & venules (blood reservoirs) Varicose veins : dilated veins, abnormal blood flow, bulging of skin. Sphincters can close off blood flow to capillary bed. High bp stage 1: sys (140-159), dias (90-99) Provide mechanical junctions (tightly joins 2 cardiomyocytes to prevent mechanical stress)
