PSYC 455 Lecture Notes - Lecture 19: Treatment-Resistant Depression, Reboxetine, Duloxetine
26 Apr 2018
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PSYC 455
Lecture 19 – Depression Drugs
• Depression (Continued)
1. Recall (depression treatment):
a. ECT
b. TCA
c. MAOI’s
2. Antidepressants:
a. Include:
- SSRI’s Serotoi Seletie Reuptake Ihiitors:
i. Facts:
Wide TI
Act on the SERT
Lower side effects:
Nausea
Sexual loss (i.e. loss of libido, absent orgasm, erectile
dysfunction)
First lass of SSRI’s:
Fluoxetine (Prozac)
- NSRI’s Norepiephrie Seletie Reuptake Inhibitors; e.g., Reboxetine)
i. Facts:
Wide TI
Act on the NET
- SNRI’s Serotoi/Norepiephrie Seletie Reuptake Inhibitors; e.g.,
Duloxetine):
i. Facts:
Wide TI
Act on the SERT and NET
- Atypical (Wellbutrin):
i. Facts:
Acts as a DAT and SERT inhibitor
Helps people not want to smoke
- Ketamine:
i. Facts:
Used to help people with treatment resistant depression
NMDA channel blocker
Taken recreationally as Special K
New drug (not really an antidepressant yet)
b. How do they (i.e. SSRIs, NSRIs, SNRIs, TCA, MAOIs) work?
- Recall:
i. Not enough 5-HT causes depression
- Antidepressants take a minimum of 2 weeks to work:
i. After about 2 or 3 weeks of having the SERT blocked (if we are looking
at SSRIs), 5-HT receptors desensitize (i.e. no longer sensitive to
elevated levels of serotonin in the synapse, so it allows the neuron to
start releasing serotonin again)
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Document Summary
Lecture 19 depression drugs: depression (continued, recall (depression treatment), ect, tca, maoi"s, antidepressants, include: Sexual loss (i. e. loss of libido, absent orgasm, erectile dysfunction) Nsri"s (cid:894)norepi(cid:374)ephri(cid:374)e sele(cid:272)ti(cid:448)e reuptake inhibitors; e. g. , reboxetine) Acts as a dat and sert inhibitor. Used to help people with treatment resistant depression. Antidepressants take a minimum of 2 weeks to work: Lecture 19 depression drugs: monoamine hypothesis of depression, depression is the functioning of a deficiency in serotonin, or norepinephrine, or both, antidepressant actions, model, antidepressants effects on post-synaptic gpcr"s i(cid:374)(cid:272)rease (cid:272)amp: camp stimulates pka: If you elevate pka, then you elevate pcreb (phosphorylated camp. Response element binding protein; i. e. this is only seen after drugs have been taken for a long time chronic dose of antidepressants, but not acute): Binds to dna and regulates protein transcription (i. e. pcreb is the active form of creb): overexpression of creb in hippocampus has antidepressant like effects.
