PSYC 355 Lecture Notes - Lecture 13: Diglyceride, Protein Kinase A, Cytotoxicity

• School: Concordia University
• Department: Psychology
• Course: PSYC 355
• Professor: All

Document Summary

Phosphatidylinositol is the most ubiquitous second messenger to mammals. Phosphatidylinositol = phosphated fatty acid and a sugar. The g protein has to activate an enzyme. The g protein is going to hydrolyze the pip2 (phosphatidylinositol 4,5-bisphosphate) that is in the membrane. called phospholipase c or plc. messengers; diacylglycerol (dag) and inositol triphosphate (ip3). kinases by binding to the regulatory subunit and. Diacylglycerol activates calcium dependent allowing the catalytic activity. Dag also serves as a calcium transporter inside to cell ot the c kinase. Inositol triphosphate binds to inositol receptors that are on the endoplasmic reticulum, allowing the liberation of calcium. The calcium can then bind to calcium cam kinases to activate inactive proteins. The liberated calcium can also be attracted by the dag to activate calcium dependent kinases. Ip3 is a sugar molecule with 3 phosphate groups. Ip3 loses, through its metabolism, each phosphate group. Dag goes through a metabolic process also.