PSYC 3403 Lecture Notes - Lecture 5: Methaqualone, Gaba Receptor, Barbiturate
23 Feb 2016
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10/08/2014 (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Chapter 13 more depressants: sedative hypnotic & anxiolytic meds. Phenobarbital was introduced as a sedative in 1912. Depress polysynaptic diffuse brain stem neuronal pathways in: the brainstem, cerebral cortex. Reduction of excitatory activity or increased inhibitory activity (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) (cid:1) Research has shown: barbiturates act as nmdar antagonists, amnestic properties due to changes in glutamatergic transmission, lower blood flow to brains areas associated with memory. Current research shows the involvement of gabaa receptors. Increased cl- influx accounts for: sedative-hypnotic actions, anesthetic properties. Can open cl- channel in the absence of gaba. High doses can produce amnesia and a state of dementia. In demented state 5 of 12 components are altered: sensorium (oriented to time and place, affect (expression of feelings, mental content (fund of knowledge, intellectual function (ability to reason, insight and judgment. Wide range of half lives (3 min to 120h)
