PSYC 3403 Lecture Notes - Lecture 6: Muscle Tone, 5-Ht1A Receptor, Blood Plasma
4 Oct 2017
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Barbiturates: phenobarbital was introduced as a sedative in 1912, originally mechanism of action was unknown, i"m going to give this medicine to someone and see what happens. There are three spots where things can bind. You can make a different barbiturate for each binding point. Barbiturates (glutamate: research has shown, barbiturates act as nmdar, usually binds with glucose. Glutamate is no longer able to bind and this decreases the excitatory in the brain: amnestic properties due to changes in glutamatergic transmission, lower blood flow to brain areas associated with memory. Barbiturates (gabaa: current research shows the involvement of gabaa receptors, enhancement of gaba transmission. Increased ci (chloride) influx accounts for (negative charge: sedative-hypnotic, anaesthetics properties, receptors have more than one binding site. It can have several: can open ci channel in absence of gaba, you usually need gaba to activate the gaba receptor, but not with barbiturates.
