PSYC 3403 Lecture Notes - Lecture 7: Cyp1A2, Lethal Dose, Paraxanthine

• School: Carleton University
• Department: Psychology
• Course: PSYC 3403
• Professor: Tarry Ahuja

Document Summary

The most commonly consumed psychoactive drug in the world. Consumed daily by 90% of the adult population. No restrictions on the sale or use of caffeine. Consumed in the stone age to 3000 bc. Freely and equally distributed throughout total body (will get various effects) 10% of the drug is excreted unchanged (body has more than it can handle) Theobromine: dilates blood vessels and increases urine volume. Theophylline: relaxes smooth muscles of bronchi, used to treat asthma. Metabolized by cyp1a2: having low levels of it will affect you more. Fluvoxamine (ssri) potent inhibitor of cyp1a2: 2 cups of coffee could = to 6 cups. Heavy consumption (1. 5g/day): agitation, anxiety, tremors. Anxiogenic (produces anxiety) properties must be considered. Caffeinism: clinical syndrome: cns (center) and pns (peripheral) symptoms, due to overuse/overdose of caffeine, cns- anxiety/agitation/insomnia, pns- tachycardia/hypertension/gi. Competitive inhibitor: caffeine blocks inhibitors in order to speed up processes (removes the brakes) Adenosine receptors stimulate gabaergic neurons in dopamine reward system.