NEUR 3200 Lecture Notes - Lecture 8: Sensory Neuron, Eric Kandel, Synapsin
8 Dec 2015
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Document Summary
Focus on the ca3-ca1 synapse in the mammalian hippocampus. Ability of nervous systems to change, physically and chemically. Allows adaptation to environmental change, changes to the body, and compensation for injury. Neuroplasticity is a property, in part, of the synapse. Synapses adapt in response to past experience. One of the locations at which learning is manifest. Multiple memory systems are present in the brain. Short- and long-term memory formation involves change in existing neural circuits. Changes may involve multiple cellular mechanisms within individual neurons. Changes can involve signaling through second-messenger pathways. Changes can involve altered number or sensitivity of ion channels. Changes can involve new protein synthesis for long-term, but not short-term memory. Changes last for >30 minutes, potentially years. Rapid and repeated stimulation (tetanus) typically causes a progressive increase in epsp. When stimulus stops, epsp decays as rapidly as it increased. Can occur with just 2 closely arriving aps.
