NEUR 2200 Lecture Notes - Lecture 7: Inotrope, Neurotransmission, Reuptake

• School: Carleton University
• Department: Neuroscience
• Course: NEUR 2200
• Professor: Matthew Holahan

Document Summary

Step 1: synthesized and stored in the axon terminal. Synthesized in the axon terminal: one part from the dna synthesis and the other from building blocks from food (amino acids) are put into cell via transporters through bbb from the blood (recycled once used in synaptic cleft) Synthesized in the cell body: completely formed by instructions from dna in the nucleus and then sent to axon terminals by microtubules. Step 2: transported to pre-synaptic membrane and released in response to an action potential. At the terminal the action potential open voltage sensitive calcium channels, enters terminal and bind the calmodulin forming a complex. This cause the vesicles to empty their neurotransmitter into the synaptic cleft. And others will get ready to empty their contents. Step 3: activate receptors (also protei(cid:374)s) o(cid:374) the target (cid:272)ell s post sy(cid:374)apti(cid:272) (cid:373)e(cid:373)(cid:271)ra(cid:374)e. Then neurotransmitters binds to the post-synaptic receptors.