HLSC 1F90 Lecture Notes - Lecture 17: Fibroblast, Unsaturated Fat, Transforming Growth Factor Beta
7 Mar 2016
School
Department
Course
Professor
Document Summary
Fragility fracture most commonly occurs in the spine, hip and wrist. Occurs as a result from minor injury (falling from standing height), reaching, twisting, bending, sneezing. Can result in chronic pain, fear of falling loss of independence, and long-term disability. More incidence of osteoporotic fractures than heart attack, stroke, and breast cancer combined. Risk of re-fracture is 1 in 3 within 1 yr. Mortality 28% of women with a hip fracture die within 1 yr. Genetics, small-boned , no physical activity, early menopause (loss of estrogen), some medications (corticosteroids, anticonvulsants), smoking, alcohol (>2 drinks/day), excessive caffeine, other nutritional inadequacies, aging. Definition (who): skeletal disorder characterized by compromised bone strength (measuring bone quantity, mineral bmd and bone quality-prior fracture/structure) predisposing a person to an increased risk of fracture. Humans, animal models (developmental changes, response to interventions) Gene and protein markers of bone health. Bone turnover (histology, biochemical markers such as blood test/urine test to determine protein)
