BIOL 2P98 Lecture Notes - Lecture 24: Gerhard Domagk, Thiazolidine, Folic Acid
9 Aug 2015
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Antibiotic discovery: usefulness of molds known to ancients, alexander fleming found penicillin in 1929, drug forgotten, thought it was unstable, howard florey rediscovered penicillin - 1940, gerhard domagk sulfa drugs. In 1928, sir alexander fleming observed that colonies of the bacterium staphylococcus aureus could be destroyed by the mold. Use of penicillin did not begin until the 1940s when howard florey and. Ernst chain isolated the active ingredient and developed a powdery form of the medicine. beta-lactam ring and thiazolidine ring. Penicillin and its derivatives: penicillium chrysogenum effectual against gram+ organisms. This morphogenic effect of penicillin on bacillus cereus that had been cultured in the absence of penicillin (left-hand image) or in the presence of a low concentration of the penicillin derivative termed ampicillin (right-hand image). By affecting the cross-linking of the bacterial cell wall, penicillin has caused the bacterium to grow as larger cells with less frequent cell divisions.
