CHEM 183 Lecture Notes - Lecture 4: Peoria, Illinois, Milk Bottle, Ernst Boris Chain

• School: McGill University
• Department: Chemistry
• Course: CHEM 183
• Professor: David Noble Harpp

Document Summary

Isolated the penicillin from penicillin notatum: but fleming, chain, and flemming got nobel prize in 1945, production was a problem; it was very tedious; grown in milk bottle. Yield of penicillin from the mold is . 0001. In order to get 1 gram of penicillin, you need to treat 1000 kg of penicillin notatum mould: albert alexander 1941 first penicillin trial. Cut after shaving, cut got worse, treated with penicillin by injection. In 1941, there was a blitz in london (bombs thrown constantly during ww) thus researching to increase production was problem thus move to usa: to increase yield in penicillin, they must find. To produce larger scale (as before it was produced in a milk bottle) Found a rotten cantaloupe and brought it back to the lab. Better mold that"s more effective in producing penicillin: wwii, main problem was venereal diseases (gonorrhea, penicillin was effective but very expensive to use due to lack of production.