BIOL 1F25 Lecture Notes - Lecture 8: Sarcoma, Retrovirus, Oncogene
31 Oct 2016
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Document Summary
If the probability did not increase with age, it would be linear. Suppose the probability of cancer occurrence depends on 4 events. 1 in 10,000 chance of contracting cancer. Whether a cancer is stage ii or iii can depend on the specific type of cancer. Prognosis decreases as the stages of cancer progress (increase). Early evidence of cancer being a genetic disease. Early 19th century: some forms of cancer showed familial tendencies: inherited predisposition. Mid to late 20th century: many chromosomal changes were observed in tumor cells. Mid to late 20th century: dna damaging agents, mutagens", were frequently shown to be carcinogens". Rous sarcoma virus is a retrovirus. A retrovirus uses rna as its genetic material and goes into reverse mechanism. Mutating gag, pol and env, results in the deactivation of the virus. Mutating the src gene allows for the continued growth of viruses, but the src gene terminates the only the sarcoma cancer.
