IMED2004 Lecture Notes - Lecture 12: Progenitor Cell, Cellular Differentiation, Morula
25 Mar 2020
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Or how does the cell decide which path it is going to go differentiate towards: depends on signals. Cells are exposed to different diffusible signals that they are exposed to over developmental period. Transcription factors change the genes that are switched on/off. Looking at the activation of different genes to push cells towards different fates. Asymmetric cell division: where the contents of the cells were split up, symmetrically or asymmetrically and using that to understand how we get self-renewal or differentiation within those stem cell lineages. We maintain an undifferentiated stem cell, but we manage to differentiate many different cell types using this asymmetric process. Every different tissue type- vary from very short to extremely long. The cells of our eye no turning of the cells in those tissues at all to a certain extent. Small intestine- replaced every 2 to 4 days.
