BIOL1130 Lecture Notes - Lecture 8: Deoxycytidine Triphosphate, Hydrogen Bond, Semiconservative Replication

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DNA LECTURE SLIDES ARE IMPORTANT SHOW STRUCTURES!!!
Heritability
Earth life stores its heritable information in the form of DNA
DNA
DNA is a nucleic acid; a polymer made of four kinds of nucleotides
To understand the concepts and jargon of DN science, the chemical
structure and numbering system of these organic molecules is essential
background
All nucleotides have a common type of structure
DNA Structure pentose sugars
Nitrogenous base + pentose monosaccharide + phosphate
The sugar in nucleotides is a type of ribose (5C)
The sugar carbons are designated , , , , 
The nitrogenous bas joins to the  carbon
The  carbon has an hydroxyl group (-OH) and a-H
The  carbon is joined to a phosphate group
DNA Structure phosphate group
The  carbon is joined to a phosphate group
The next nucleotide in the chain is joined to the other end of the
phosphate group at the position of its C, through the  OH group
This joining involves a condensation reaction making DNA a polymer
The bond is called a phosphodiester bond
The sugar-phosphate part of the DNA strand is called the backbone
DNA structure nitrogenous base
The  carbon is joined to a nitrogenous base
A base is a chemical that attracts protons (H+)
It is a nitrogenous base: protons are attracted to a nitrogen in the
molecule
DNA structure names and abbreviations
DNA = deoxyribonucleic acid
It is an acid not a base because of the double-stranded structure
The bases are bonded and inside the ladder structure, protected from
aqueous environment
Single stranded nucleic acids also fold up by internal base pairing so the
base is protected
The sugar phosphate backbone on the outside is acidic giving this
biomolecule its name.
DNA structure nomenclature and abbreviations
RNA bases
o A= adenosine
o G= guanosine
o C= cytidine
o U= uridine
DNA bases
o dA= deoxyadenosine
o dG= deoxyguanosine
o dC= deoxycytidine
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