PHA3801 Lecture Notes - Lecture 2: Propranolol, Antithrombotic, Collecting Duct System
24 Jul 2018
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Control of bp: pump, volume of blood through distensible reticulation. Depends on co + pvr (peripheral vascular resistance). The system can sense the bp and react to maintain within range. Hr: controlled by para/sympathetic tone balance - ans. Stroke volume: (v ejected per stroke) controlled by: total blood volume (frank-starling effect), and contractility controlled by sympathetic tone (= strength of contraction higher c more blood ejected from heart w each contraction). Pvr: controlled by ans, renin-angiontensin system + no. Co (l/min) = sv x hr ~ 5l/min. Pvr: ans, renin-angiotensin system + no (local vasodilator) Ans regulates bp by effects on both pump output + resistance in circulation. Vasomotor system within brainstem = parasympathetic (vagus), sympathetic ( b1 to inc hr + contractility, and a1 acting on arteriole (most influential for pvr muscular wall) to affect. Keeping bp within normal range: feedback mechanism involves carotid sinus, baroreceptors, measure bp instruct more/less para/sympathetic tone.
