GENE20001 Lecture 28: 28 Genetic drift B
Document Summary
No. of mutations that will arise at that locus is 2nu. Probability that any given mutation is fixed is 1/2n (since new allele has frequency of. 1/2n) (probability of elimination is 1 - 1/2n) No. of mutations fixed per generation per locus is u. Scientists have used this as a molecular clock. Value of n has opposing effects with regard to mutations and their eventual fixation. However each new mutation has a greater chance of being eliminated from population due to random genetic drift. New mutation has a greater chance of being fixed from population due to random genetic drift. Time fixation: . is the average number of generations to achieve fixation. N is the number of individuals in the population assuming males and females contribute equally to the next generation. As expected allele fixation takes longer in large populations. Only a few mutations become fixed due to genetic drift. Scoring for frequency of a chromosomal inversion called pp.
