BCMB30011 Lecture 17: LECTURE 17 - FACTORS REGULATING BLOOD LIPID LEVELS - POSSIBLE TARGETS FOR LIPID-LOWERING THERAPY

• School: University of Melbourne
• Department: Biochemistry and Molecular Biology
• Course: BCMB30011
• Professor: professor watt

Document Summary

Factors regulating blood lipid levels possible targes. * inhibition of hmg-coa reductase activity, the rate-limiting step in cholesterol synthesis. * decreasing absorption and increasing disposal of cholesterol from the body. * other mechanisms: modification to the diet: * acc/aha guidelines -the guidelines brought together recommendations form a range of earlier guidelines that supported the use of diet and physical activity to improve lipid and blood pressure control. * it can be quite difficult to alter blood lipids of cholesterol levels particular by diet, tags is a different story. You have to be incredibly rigorous with your diet to make a difference to total cholesterol levels. * investigation of dose-response between eggs and the occurs of coronary heart disease and stroke. * meta analysis (contrasting & combing results from several different studies) of prospective cohort studies (i. e. those that follow a group of similar individual over time) 3,081,269 person years and 5,847 incident cases for coronary heart disease.