PHTY205 Lecture Notes - Lecture 10: Mucociliary Clearance, Cough Reflex, Adrenergic Agonist
Document Summary
Describe the two (2) mechanisms of airway clearance. Sneeze, cough, huff: mucociliary clearance (mcc, primary clearance mechanism of the airways, protection mechanism of the lungs, mcc apparatus consists of, mucus (2 layers) Functions as a mechanical, chemical and biological barrier. Sol layer (periciliary fluid layer: thin, watery/aqueous fluid bathes the cilia, provides minimal resistance to cilial movement, gel layer (mucus layer, non-newtonian fluid, viscosity, elasticity. Filance: cilia, moves particulate material caught in mucus towards the pharynx, lung secretions, normal amount = 10-100ml/day, mucus produced by. Submucosal glands: goblet cells, clara cells, type ii alveolar cells, consists of, h2o, dna, cellular debris, trapped foreign matter, glycoproteins (mucins) Lipids: cilial movement, green - effective stroke, red - recovery. Describe how mucociliary clearance can be impaired and provide examples of conditions/situations where this may occur. Factors influencing mcc: age: (cid:449)ith age, posture: can assist, sleep: , e(cid:454)er(cid:272)ise: duri(cid:374)g, e(cid:374)(cid:448)iro(cid:374)(cid:373)e(cid:374)t: (cid:449)ith i(cid:374)haled parti(cid:272)ulate (cid:373)atter, disease/i(cid:374)jur(cid:455): (cid:373)a(cid:455) , reasons for impaired secretion movement.
