PHYL 4504 Lecture Notes - Lecture 16: Mucociliary Clearance, Antimicrobial Peptides, Oxidative Stress
6 Jan 2021
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Phyl 4504 lecture 16 november 2, 2020 airway host defense and oxidative stress. Explain mucociliary clearance and list factors and diseases that affect its efficiency. Explain how mucus is secreted and list its components. Provide evidence that ros may be implicated in the pathophysiology and cf and asthma. Airway host defense: why and how: approximately 12,000l of air passes through the lungs every day, contains millions of foreign particles: mold spores, bacteria, viruses, environmental pollutants, cigarette smoke , airways are (usually) sterile and particle free. Series of defense mechanisms that protect airways: physical, cough, barrier function, chemical, mucociliary clearance, mucus composition and viscosity, antimicrobial peptides, cellular, phagocytosis by macrophages. Clearance of inhaled material is determined by their size. Impaction: largest particles fail to turn at the corners of the respiratory tract (back of throat, nasal turbinate). 95% particles > 5 m filtered by nose. Sedimentation: gradual settling of particles due to their weight.
