PCB 3233 Chapter Notes - Chapter 8: High Endothelial Venules, Mhc Class I, Adaptive Immune System
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18 Nov 2017
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If an infecting pathogen successfully resists the innate immune response, the adaptive immune response is brought into play with the activation of t cells. Selection of t cells that will attack the pathogen. Some types of effector t cell travel to infected tissue to work on the front line of defense: other types stay in the lymphoid tissues to continue developing more weaponry. If infection is not lethal: dendritic cells can carry the virus to the draining lymph node and activate na ve virus-specific cd8 t cells. Signals from tlr"s --> change the pattern of gene expression --> cell"s activation. Increase the efficiency with which antigens are taken up, processed, and presented by mhc class ii molecules: appearance of ccr7 (receptor for ccl21): Signals induced by the interaction of ccl21 with ccr7 cause the pathogen-loaded and migratory dendritic cells to leave the lymph and enter the tissue of the draining lymph node.
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