PCB 3233 Lecture Notes - Lecture 1: Hyper Igm Syndrome, Follicular Dendritic Cells, Follicular B Helper T Cells
Document Summary
Know the different cells that can become plasma cells. What are the components of the b cell co-receptor (cr2 is one of them) 1) memory b cells, activated b cells and centrocyte. Binding of cr1 on the b cell to c3b on the pathogen leads to cleavage by factor i and results in c3d, c3d can bind with cr2 (part of co receptor) Thymus independent, thymus dependent; td activate b cells in the 2nd lt. Describe b cell activation, cd40 ligand, cd40, nf b, icam-1 and il-4 secretion by t cells. After t cells and b cells form a conjugate pair, the t cells are induced to express cd40 ligand which bings to cd40; the binding activates nfkb which increases expression of the adhesion molecule icam-1. They bind and link the pathogen to an effector cell that will destroy the pathogen. Medullary cords where is this and what is the major isotype made here. lymphobloasts: medullary cords e. f.
