BIO SCI 98 Chapter Notes - Chapter 20: Bzip Domain, Helix-Turn-Helix, Dna-Binding Domain
19 Jun 2018
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the way the base pairs are read depend on the major groove and the minor groove
4 different chemical patterns
transcription factors have conserved structure and differnt properties
hybrids of different motifs
need to 1) recognize and bind DNA sequences 2) regulatory domain --> blocks DNA unwinding,
recruit RNA polymerase site
functional activty on probe --> dimerization
strucutral motifs --> helix turn helix
2 alpha connected by beta turn
homeodomains ---> domain of transcription factor
read info in major groove --> more info found in major groove
some binding to minor groove
first discovered in fruit flies
regulated by hox transcription factors
mutation in transcription factors can cause mutation on body parts like extra wings or massive
antennae
like flies, we have segmentss
embryo derived of different segments
toes and fingers
hox genes critical to humans --> mutations are lethal
basic leucine zipper - transcription factor
clamps on either side of ssDNA
basic helic loop helix
zinc finger motifs
transcription factor binds to promoter sequence and recruits polymerase and other proteins -->
facilitate recruitment
conformation change in RNA pol
DNA binding domain
activating domain
can be cut in between to form diff transcription factors
there is only a few signma factors vs a lot of genes
transcription regulated by sigma factors --> circuit board
reulators --> light switches around house
E coli
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