BIO230H1 Chapter Notes - Chapter 8: Sh2 Domain, Autocrine Signalling, Phosphatidylinositol
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BIO230H1 Full Course Notes
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Document Summary
Extracellular signals can act over short or long distances. Contact -dependent: requires cell to be in direct membrane-membrane contact. Can do over long distance if communicating cells extend long process. Paracrine: depends on local merited that are released into the extracellular space act on neighboring cells. If cell produce signals that they respond to: autocrine signalling. Synaptic signaling: neurons release nt at synapses, often far away. Endocrine signaling through blood to all over her body. Cell surface receptors relay signals via intracellular signaling molecules. There are three major classes of cell-surface receptor proteins. Modular interaction domains mediate interactions between intracellular signalling pathway. Src homology 2 (sh2) and ptb - phosphotyrosine-binding domains. Bind to phosphorylated tyrosine on receptor or interacting protein. Bind to proline rich amino acid sequence. Pleckstrin homology (ph): charged hedgroud of phosphoinositide. Some signaling proteins consist of two or more interaction domain and function as adaptor.
