BIOA01H3 Chapter Notes - Chapter 9: Joshua Lederberg, Fertility Factor (Bacteria), Genetic Recombination
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Most of the recombination occurs between regions of dna that are very similar but not identical homologous. In order for lederberg and tatum to detect genetic recombination, they. Escherichia coli (e. coli) extracted from a diaper during a diarrhea outbreak in 1885 named after viennese pediatrician theodore escherich. 1946 joshua lederberg and edward tatum set out to determine if genetic recombination occurred in bacteria using e. coli as their experimental organism. Strains that were able to synthesize necessary amino acids prototrophs; strains unable to synthesize amino acids auxotrophs (auxotrophs can only grow if the required amino acid is provided in the growth medium) A strain that cannot manufacture its own arginine is represented as: arga- (a form of mutation) A strain that can manufacture its own arginine is written as arga+ (this naming can be used for any other amino acids or mutations present in an organism) Lederbeg-tatum experiment further detail (p. 184 figures 9. 2-9. 3)
