PAT 20A/B Chapter Notes - Chapter 17: Alternative Complement Pathway, Innate Immune System, Cytokine Receptor
22 Sep 2016
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Document Summary
The innate immune system can communicate information about an invader and self-non-self through cell to cell contact. Soluble mediators such as; opsonins, cytokines, acute-phase proteins help regulate behaviours of effector cells and develop innate immunity. Opsonization: coating of particles like microbes, coating of an antigen with antibody or complement to enhance binding. Opsonin bound to microbes activate phagocyte after attachment to a complementary receptor on the phagocyte. Important opsonins in innate immunity and acute inflammation: acute-phase proteins, lectins, complement. With the activation of the adaptive humeral immunity, antibodies can coat microbe and act as an opsonin by binding to fc receptors on neutrophils and macrophages. Adaptive immune response: can enhance phagocytic function of innate cells. Interleukins (il1, 6, 12), interferons (ifn alpha, beta, y), chemokines, tnl-alpha are involved in innate immunity. Part of integrated signalling network with extension functions. Produce chemotaxis of leukocytes, stimulate acute-phase protein production, inhibit virus replication, affect development of cells in innate and adaptive immune systems.
