NURS 165 Study Guide - Final Guide: Myopathy, Headache, Bioavailability
PUD Drugs
Drug
Indication
MOA
Advantage
Disadvantage
Side Effects
Antacids
neutralize gastric
acidity
maintains gastric pH>4,
thereby dec. pepsin
production, may also increase
LES pressure
inexpensive
requires frequent
administation
constipation (Al),
diarrhea (mag),
bone
demineralization
(Al)
Proton Pump
Inhibitors (PPI)
GERD, PUD,
hypersecretory
disorders
inihibits the H+K+ATPase
pump
superior to H2RAs in
mod-severe disease
takes 3-4days for full
effect; the drug
degrades in acidic
environment;
metabolized by
CYP2C19
Histamine2 Receptor
Antagonists (H2RAs)
GERD, PUD,
hypersecretory
disorders
inhibit histamine-stimulated
acid secretion
symptomatic relief
for most patients
with GERD and
nonHP or nonNSAID
induced PUD
tolerance with
continued dosing,
CYP inhibition, poor
protection from PUD
re-bleeding
Drug
Indication
MOA
Other
Side Effects
Other
Omeprazole
(PPI)
GERD, GU, DU,
hypersecretory states
reduces HCl secretion
from parietal cells by
inhibiting
H+K+ATPase activity
headache, dizziness,
somnolence, GI
complaints (NCD),
hypergastremia, vit
B12 deficiency
myopathy, arthralgia
Ranitidine (H2RA)
GERD, GU, DU, other
hypersecretory states
reduces HCl secretion
from parietal cells by
blocking H2 receptors
headache, somnolence,
fatigue, dizziness,
constipation/diarrhea,
confusion, slurred
speech, delirium,
hallucination
interacts antacids-
reduces bioavailability
Sucralfate (Mucosal
Protectant)
duodenal ulcers
blocks pepsin action,
local PG and EGF
stimulation, mucosal
surface protection
adv- non-absorbed
disadv- Al absorption
possible in CKD pts,
reqs. pH<4 for optimal
action
dry mouth, nausea,
constipation,
hypophosphatemia
caution gastroparesis
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Document Summary
Moa maintains gastric ph>4, thereby dec. pepsin production, may also increase. Gerd, pud, hypersecretory disorders inihibits the h+k+atpase pump superior to h2ras in mod-severe disease. Gerd, pud, hypersecretory disorders inhibit histamine-stimulated acid secretion symptomatic relief for most patients with gerd and nonhp or nonnsaid induced pud takes 3-4days for full effect; the drug degrades in acidic environment; metabolized by. Side effects constipation (al), diarrhea (mag), bone demineralization (al) Moa reduces hcl secretion from parietal cells by inhibiting. Other reduces hcl secretion from parietal cells by blocking h2 receptors. Protectant) duodenal ulcers blocks pepsin action, local pg and egf stimulation, mucosal surface protection adv- non-absorbed disadv- al absorption possible in ckd pts, reqs. ph<4 for optimal action. Side effects headache, dizziness, somnolence, gi complaints (ncd), hypergastremia, vit. B12 deficiency headache, somnolence, fatigue, dizziness, constipation/diarrhea, confusion, slurred speech, delirium, hallucination dry mouth, nausea, constipation, hypophosphatemia.
