NURS 165 Study Guide - Final Guide: Orlistat, Leptin, Sympathomimetic Drug
Obesity Drugs
Hyperlipidemia
Weight Loss
Drug
Class
MOA
Indication
Other
Side Effects
Other
LT
Orlistat
Lipase Inhibitor
inhibits gastric/pancreatic
lipases, dec. absorption of
dietary fat
promo&maint.
of weight loss
in obese pts
**multivit
supplement daily
(fat soluble- ADEK)
fecal urgency/
incontinence, oily stools,
Vit deficiency, liver
disease, kidney stones or
acute pancreatitis
contra
malabsorption
cases
ST
Phentermine
Sympathomimetic
amines
suppresses appetite
(hypothalamus-> adrenal-
> NE released)
weight loss
give 2nd dose late
afternoon bc of
night sympathetic
activity
insomnia, irritability,
convulsions, withdrawal,
depression, tachycardia,
angina, HTN, rebound
weight gain
ETOH
interaction
Siethylpropion
-
suppresses appetite, inc.
release of Dopamine and
NE availability, raises
leptin levels (satiety)
^^same
max 3 mos
insomnia, irritability,
withdrawal, depression,
tachycardia, angina, HTN
ETOH
interaction
Drug
Class
MOA
Indication
Other
Side Effects
Other
Pravastatin
HMG-CoA-
reductase
inhibitors
dec. cholesterol synthesis,
inc. LDL receptors
primary/secondary
CHD prevention in
@risk pts
taken at
bedtime
GI complaints,
hepatotoxicity, myopathy,
rhabdomyolysis
rash, caution in
preg
Gemfibrozil
Fibrate
dec. VLDL via PPAR-alpha
activation (dec. TRG, inc.
HDL)
elevated TRG
taken 30 min
before meal,
takes 3-4 weeks
onset
nausea, abdominal pain,
diarrhea, gallstone risk,
hepatotoxicity, myopathy
rash
Niacin
Nicotonic acid
dec. VLDL production, dec.
LDL, tRG, inc. HDL
elevated TRG,
mixed
hyperlipidemia
facial flushing,
nausea/vomiting, liver
dysfunction,
hyperglycemia
itching, aspirin
interaction
Vascepa
Omega 3 FAs
eicosapentaenoic acid
(EPA)- only omega-2,
reduces TRG synthesis,
and enhances TG
clearance from plasma
lowers TRG (w/out
inc. in LDL)-
adjunct to diet
pancreatitis, joint pain,
sore throat
itching
Ezetimibe
Cholesterol
absorption
blocker
dec. intestinal cholesterol
absorption
elevated
cholesterol, adjunct
therapy
rare myopathy,
rhabdomyolysis, hepatitis,
pancreatitis,
thrombocytopenia,
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Document Summary
Moa dec. cholesterol synthesis, inc. ldl receptors dec. vldl via ppar-alpha activation (dec. trg, inc. @risk pts elevated trg dec. vldl production, dec. Ldl, trg, inc. hdl elevated trg, mixed hyperlipidemia. Gi complaints, hepatotoxicity, myopathy, rhabdomyolysis nausea, abdominal pain, diarrhea, gallstone risk, hepatotoxicity, myopathy. Other rash, caution in preg rash facial flushing, nausea/vomiting, liver dysfunction, hyperglycemia pancreatitis, joint pain, sore throat itching, aspirin interaction itching rare myopathy, rhabdomyolysis, hepatitis, pancreatitis, thrombocytopenia, Moa inhibits gastric/pancreatic lipases, dec. absorption of dietary fat. Indication promo&maint. of weight loss in obese pts. Siethylpropion suppresses appetite, inc. release of dopamine and. Ne availability, raises leptin levels (satiety) give 2nd dose late afternoon bc of night sympathetic activity. Vit deficiency, liver disease, kidney stones or acute pancreatitis insomnia, irritability, convulsions, withdrawal, depression, tachycardia, angina, htn, rebound weight gain insomnia, irritability, withdrawal, depression, tachycardia, angina, htn.
