NURS 165 Study Guide - Final Guide: Tissue Plasminogen Activator, Plasmin, Enoxaparin Sodium
ACS
Drug
Indication
Mechanism
Onset
Duration
Elimination
Adverse Effects
Caution
Interactions
Nitroglycerin
angina (SL, SR,
and patch
avaiable)
Nitrodilator
1-3min, 20-45
min, 30-60
min
30-60 min, 3-
8h , 24hrs
rapid hepatic
inactivation
headache
orthostatic
hyportension, reflex
tachycardia
antiHTNs,
phospodiesterase
inhibitors
Isosorbide
Dinatrate/
Mononitrate
angina (IR)
Nitrodilator
20-40min
4-6hrs
^^same
^^same
^^same
Verapamil
angina, HTN,
arrhythmias
Ca channel blocker
(nondihydropiridine)
within 30 min
~5h
extensive 1st
pass effect,
hepatic
constipation,
peripheral edema,
dizziness, headache,
flushing, AV block
heart block
digoxin, beta-
blockers
Metoprolol
HTN, angina,
MI, HF
anti-adrenergic
(direct, selective Beta
1 antagonist)
hepatic metb,
renal
bradycardia, AV
heart block, HF,
rebound cardiac
excitation, heart
block
heart block
other
antihypertensives
Propranolol
HTN, angina,
MI, cardiac
arrhythmias
Anti-andrenergic
agent (nonselective
beta1/2 blocker)
decreases AV
conduction, HR, and
contractility
hepatic
metabolism,
renal excretion
bradycardia, AV
heart block, HF,
rebound cardiac
excitation,
bronchoconstriction,
inhibition of
glycogenolysis, CNS
effects
Ca channel blockers
Aspirin
1° and 2°
prevention of
CVD
Antiplatelet (Inhibits
COX1&COX2)
30-60 min
4 hrs
hepatic, then
renal
GI distress, tinnitus,
altered hemostasis,
renal dysfunction
hypersensitivity
RXNs
Clopidogrel
2ndary
prevention of
CVD
Antiplatelet (ADP
antagonist)
30-60 min
7-8 hrs
hepatic then
renal
bleeding, dyspepsia,
abdominal pain
rash, TTP
Abciximab
decrease
complications
of PCI/ ACS
Antiplatelet
(GpIIb/IIIa
antagonist)
rapid (IV)
10-30 min
renal?
bleeding
hypersensitivity
Heparin
(UFH)
treatment/
prevention of
thrombosis
(MI, DVT, PE,
stroke, postop
VT, open heart
surgery)
Anticoagulant
(antithrombin
activator)
minutes
1.5 hrs
hepatic
metabolism,
renal
bleeding
HIT
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