NURS 165 Study Guide - Final Guide: Asthma, Cysteinyl Leukotriene Receptor 1, Budesonide
Asthma Drugs
Class
Mechanism
Drug
Specific
Mechanism
Indication
Onset/
Duration
Metabolism
Side Effects
Adverse RXNs
Interactions
Bronchodilators
B-Adrenergic
Agonist
Albuterol
bronchial
smooth muscle
asthma, acute
bronchospasm,
EIB prevention
<2min/ 3-
5h
COMT/ MAO
tremor,
tachycardia,
palpitations,
chest pain;
hypokalemia,
hyperglycemia,
dysrhythmia
sympathomimetics,
tricyclic
antidepressants,
MAO-inhibitors
Anticholinergic
Ipratropium
muscarinic
receptor
antagonist
asthma
~30-
60min/ 6-
8h
minimal
systemic
absorption
bitter taste,
headache,
glaucoma,
rebound
airway
responsiveness
rare
bronchoconstriction
anticholinergics
Phospho-
diesterase
Inhibitor
Anti-
Inflammatory
Agents
Corticosteroid
(Inhaled)
Budesonide
decreased
mediator
synthesis,
release, and
infiltration of
inflammatory
cells
prophylactic/
maintenance
of asthma
~4-6h
(onset)
cough, some
adrenal
suppression,
some bone
loss, bruising,
hyperglycemia,
cataract and
glaucoma
possible)
rash, contact
dermatitis, other
hypersensitivity
RXNs
CYP3A4 inhibitors
Corticosteroid
(Systemic)
Mast Cell
Stabilizer
Leukotriene
Modifier
Montelukast
Cys-LT1
receptor
antagonist
asthma (incl.
exercide-
induced) and
prophylaxis
w/in hrs/
at least
24h
CYP3A4,
CYP2C9,
highly
protein-
bound
fever, headache,
upper
respiratory
infection
thrombocytopenia,
eosinophilia, Churg-
Strauss-like
syndrome
(eosinophilic
vascuilitis, LFT
abnormalities
warfarin
Antibodies
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