CHEM 251 Study Guide - Midterm Guide: Nucleobase, Dna Supercoil, Lysine
Document Summary
Rna = single stranded, dna = double stranded. Without complementary strand, rna can fold/ make self interactions/ h bond between nucleobases. Aptamers (rna fold in greed, atp shown in stick structure, grey = nucleic acids that form binding pocket) Since rna can form protein like folds, it can also bind small molecules. They serve as metabolic sensors, pieces of rna that fold up when you have high conc of atp in cell and bind, might function to control whether rna can code for proteins at that time. Rna can take on folded shapes and binding of small molecules = sensor for whether gene gets translated as protein or not. Dna pol has just addition of nucleotides to make dna longer, but it also has a proof reading domain when there"s a mispair (it can be cut out) - didn"t cover this in lecture. Don"t need to know supercoiling stuff on the right of slide.
