BIBB 251 Study Guide - Midterm Guide: Rectifier, Sensory Neuron, Aplysia

• School: UPenn
• Department: Biological Basis of Behavior
• Course: BIBB 251
• Professor: Mike Kaplan

Document Summary

Epsp size (evoked) = qm: m = quantal content (number of quanta, q = quantal size. Synapsin: sticks to vesicle, holds in reserve pool. Snap25: t-snare (snare proteins are targeted by clostridial toxins like botox) Nsf: break apart snare complex asnap: break apart snare complex. Synaptotagmin: ca2+ sensor, displaces complexin to allow fusion to proceed. Do not confuse voltage at peak (vs) with the size of the synaptic potential (dvs)! At the peak (vs), synaptic and leak currents are equal and opposite. Ionotropic synapses with erev lower than threshold hyperpolarizing ipsp (inhibitory) Ionotropic synapses with erev higher than threshold depolarizing epsp (excitatory) Two main classes of ionotropic receptors: glutamate receptors (ampa, nmda, cys-loop (nach-r, gaba-a, gly, 5ht) *refer to channels guide for more detail on these. G-proteins are trimeric: alpha, beta, gamma subunits. Inactive form has gdp bound to alpha subunit. Gtp s* and gpp(nh)p: prolonged g-protein activation: gtp where bond between last two phosphates is different (harder to hydrolyze)