PNB 2264 Final: Anatomy Exam

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Na+ absorbed through active transport (basolateral side); symport, antiport or leaky channels (apical side) Na+ and glucose are transported across the apical surface (sodium. Na+ is pumped out (basolateral side) by na+ and k+ atpase. Glucose diffuses out of the basolateral side using glut protein. Anions go in through electrochemical gradient- transcellular and paracellular. Other stuff goes in through diffusion ex urea (passive reabsorption due to urea concentration gradient)- transcellular and paracellular. Small proteins and peptides can pass through the filtration barrier (receptor mediated endocytosis) - most filtered proteins are removed from filtrate in the proximal tubule. Loop of henle reabsorption- 30% of filtrate reaches here. Thin descending- permeable to water, moderate to urea. Thin ascending- impermeable to water, permeable to ions. Thick ascending- impermeable to water and ions but actively pumps out na+/cl- Reabsorbed 8% of filtered nacl and water. Principal cells - water reabsorption (adh sensitive) Intercalated cells- h+ and bicarb transport (ph dependent)

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