NURS 3110- Midterm Exam Guide - Comprehensive Notes for the exam ( 70 pages long!)
Document Summary
Cephalosporins: mechanism of action, disrupt cell wall synthesis, watch nerves carefully, drugs are classified by (cid:498)generation(cid:499, 1st, 2nd, 3rd, 4th, increase in gram negative coverage as generation increases, 3rd generation are newer drugs than 1st generation. The generations: as the generation increases, gram-positive activity varies, generation increases gram-negative activity increases most of the later agents also have fewer side effects and better dosing profiles, classification of cephalosporins into generations is an inexact science. B-lactamase inhibitors: have little antibiotic activity of their own (timentin, sulbactam, usually combined with ampicillin (unasyn) or cefoperazone (sulperazon, tazobactam, usually combined with piperacillin (zosyn) (tazocin, avibactam (investigational) Vancomycin: alters cell wall, binds with cell wall precursors, activity, gram positive only, adverse effects, nephrotoxicity, ototoxicity, rapid iv infusion reaction, monitoring vancomycin (cid:498)red man/ neck(cid:499) syndrome. Mrsa: new treatment options for invasive mrsa infections include, linezolid, daptomycin, tigecycline, quinupristin/dalfopristin, dalbavancin, telavancin, oritavancin, costly.
