BSCI 437 Study Guide - Midterm Guide: Macrophage, Integrase, Picornavirus
29 Mar 2017
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Three steps in entry: attachment, penetration (get to right compartment), uncoating (make genomes available: rna usually in cytosol (except influenza, dna usually in nucleus (except smallpox) Surface molecules protein, carbohydrate and lipid can serve as receptor for virus attachment. Influenza makes neuraminidase (enzyme on virus envelope that degrades own receptor/ cuts sialic acid residues: if a virus buds from a cell w/o neuraminidase, it would just stick to its birth cell, confirm that sialic acid is receptor. 3. treating cells with neuroaminidase destroys ability of flu to bind to cells reintroducing silica acid restores binding carbohydrates with sialic acid compete to bind the virus. Expression of surface molecule determines who and what gets infected: host range: host must express surface molecule, tissue tropism: tissue must express surface molecule. Example: hiv can only infect cells with cd4 and chemokine: t helper, macrophage, glial cell.
