VTPP 425 Midterm: Calculation Terms & Equations

• School: Texas A&M University
• Department: Vet Physiology & Pharm
• Course: VTPP 425
• Professor: Jones

Document Summary

Fractional volume of distribution = f (vd) Amt of drug in the body or dose = d. Elimination rate constant (% removed per unit of time) = ke (/h) Desired drug conc (final/target concentration) = c2 or c. Current drug conc (initial concentration) = c1 or co. Total body clearance = cltotal (mg) (mg) (ml/min) (mg/min) (mg/ml) Rate input (infusion rate) = ro (mg/min) or (mg/h) Amt drug required (mg) = vd x (c2 c1) Plasma clearance = renal plasma flow x extraction ratio = (renal plasma flow)(c/c0) Er = plasma clearance x plasma concentration. Cltotal= clhepatic + clrenal + cllungs or cltotal = ke x vd t1/2 = 0. 693/ke or ke = 0. 693/ t1/2. Cl = ke x vd or cl/vd = ke t1/2 = 0. 693/(cl/vd) or = 0. 693 x (vd/cl) Ro = ke x vd x css. ** cl hepatic + cl renal are typically the most important.