VTPB 405 Study Guide - Quiz Guide: Thymidine Kinase, Stavudine, Lamivudine

• School: Texas A&M University
• Department: Veterinary Pathobiology
• Course: VTPB 405
• Professor: Esteve

Document Summary

Nri competitive inhibition of hiv reverse transcriptase oh. Inhibit are nucleosides need phosphorylation x3 mitochondrial may cause. 5 phosphodiesterase bond toxicity premature chain acidosis lactic termination dine to activate last phos by thymidine kinase. Lamivudine peripheral neuropathy treat hepatitis b inhibit dna replication. Tenofovir nucleotide onlyneeds 2x phosphorylation treat hepatitis b associated w. Didanosine when given w stavudine a risk of peri neuropathy causes dose dependent pancreatitis. Emtricitabine delayed type 4 rxn rash cause hyperpigmentation of palms a soles. Viral life cycle affects macrophages dendriticcells a cd4tcells p envelope proteins gp41 gp120 env p741324 core proteins structural genes gag pot gp120 surface binds membrane fusion gp41. Viral rna released a transcribed into dsdna by rev trans. ase dsdna nucleus to infiltrate gain entry integrase resistance mut in nrtisgnnrtis pot make their move protease revtrans integrase q. Nnr 11s i non nucleoside reverse transcriptase inhibitors pr se.