BIOL 4124 : Exam 2 Ppt3

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15 Mar 2019
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The polymorphism is due to heterozygotes having a higher fitness than homozygotes: ex - sickle cell allele and other red blood cell variants, and malaria, sickle cell (hb) consists of 2 and 2 polypeptide strands. Heterozygotes for sickle cell have a lower rate of malarial infection compared to individuals homozygous for normal hemoglobin: why is heterozygotes for the sickle cell alleles advantageous, heterozygotes for sickle cell have selective destructive of rbcs. Uninfected rbcs do not sickle ,and these rbcs deliver oxygen to the tissues. Infected rbcs do sickle, and this anomalous rbc shape provides a lethal environment for parasites. Therefore, heterozygotes can both suppress parasitic proliferation and deliver oxygen to tissues. In malarial environment, heterozygotes for sickle cell have a natural selective advantage over homozygotes for normal hemoglobin and homozygotes for sickle cell and normal hemoglobin are maintained at high frequencies. Evolution of relationships between sickle cell allele and malaria: 1.

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