ORB 141 Study Guide - Midterm Guide: Gastric Acid, Adipocyte, Gastroesophageal Reflux Disease
21 Dec 2020
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Gi disorders that have oral manifestations: crohn"s disease, ulcerative colitis, celiac disease, peptic ulcer disease, h. pylori associated gastritis, gastroesophageal reflux disease (gerd), hiatial hernia related w/ gerd and anemia. Gastric h+ secretion: clinical issues bc of h2 (histamine) anatogonists, ppis, nsaids. Gerd patients have a specially high risk of developing dental erosions along w/ those on special diets, those who consume acidic beverages, and those taking certain prescription drugs regularly. Eating disorders associated with increased occurrence for dental erosion. G cell secretes gastrin and goes to ecl cell telling it to secrete histamine and the histamine goes to parietal cell to secrete h+ to combine with cl- in lumen to create ph low. Melatonin secreted by ee cell to inhibit gastric acid secretion. Sst cell secretes somatostatin also inhibiting parietal cell secretion. Ghrelin involved in stimulating appetite and therefore gastric acid secretion (orexigenic hormone) Parietal cell has a lot of active proton pumps (main stimulants = gastrin, ach, histamine)
