BCHM-3010 Midterm: BCHM 3010 Exam 2 Study Guide

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Frederick w. k hne gave name to enzymes to the molecules detected by eduard buchner. Why enzymatic catalytic opposed to chemical catalysis: higher reaction rates, milder conditions (<100 c, atmospheric pressures, near neutral ph, reaction specificity, capacity for regulation. With the exception of a small group of catalytic rna molecules, all enzymes are proteins. Catalytic activity depends on the integrity of their native protein conformation. Some enzymes require an addition chemical component called a cofactor or a complex organic metallo-organic molecule called a coenzyme. cofactors include inorganic ions such as fe2+, mg2+, mn2+, or zn2+ coenzymes act as transient carriers of specific functional groups. Coenzymes that are very tightly or even covalently bound to an enzyme protein is called a prosthetic group. A complete, catalytically active enzyme together with its bound coenzyme is called a holoenzyme. The protein part of such an enzyme is called the apoenzyme or apoprotein.

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