FORS 3331 Study Guide - Midterm Guide: Intramembranous Ossification, Bone Remodeling, Collagen

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Endochondral ossification: collar formation: periosteum forms around a piece of hyaline cartilage. The osteoblasts then secrete their organic fibers on the outside of the cartilage. The end result of this is the formation of a bony collar on the outside of the cartilage: cavity formation: the cartilage in the center of the model begins to ossify. This centered cartilage is called the primary ossification center. The calcification/hardening of the center makes the inner cartilage impermeable to the diffusion of nutrients. Many other components enter through the nutrient foramen such as nerves, lymphatics, osteoclasts, osteoblasts, nutrients etc. The remaining cartilage is broken down by osteoclasts and the osteoblasts secrete their osteoid forming spongy bone: elongation: as blood vessels, osteoclasts, and osteocytes continue to invade the bone the diaphysis will start to elongate. As a result the medullary cavity is formed and the diaphysis will slowly continue to lengthen during embryonic development.

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