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Pharmacology 2060A/B Study Guide - Final Guide: Cell Cycle, Hypersensitivity, Schizophrenia

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School
Western University
Department
Pharmacology
Course
Pharmacology 2060A/B
Professor
Di Sebastiano

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Document Summary

Decrease hepaic synthesis of cholesterol by inhibiing hmg-coa reductase (which converts. Hmg-coa to mevalonic acid, rate lim step), causing upregulaion of hepaic ldl receptors, allowing liver to remove cholesterol from blood. Inhibits secreion of vldl, reducing both vldl and ldl. Large posiively charged molecules that atract and bind bile acids (neg charge) in the intesine and prevent their absorpion, causing incr"d demand for bile acid synthesis in liver which requires ldl, so ldl receptors are increased. Blocks npc1l1 (transporter of cholesterol), decreasing intesinal absorpion of cholesterol. Rhabdomyolysis (muscle lysis with severe muscle pain), leading to hyperkalemia, acute kidney failure. Need cholesterol for cell membrane synthesis for fetuses so shouldn"t use when pregnant. Secondary prevenion studies: prevent recurrence of cv disease events. Pharmacokineics: low oral bioavailability (14%/20%), large fracion of absorbed dose extracted by liver, distribuion primarily to liver, predominantly elim"d in feces with minimal renal excreion. Atorvastain: distr"d also to spleen, adrenal glands, skeletal muscle; metab"d by cyp3a4.

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