Pharmacology 2060A/B Study Guide - Midterm Guide: Single-Nucleotide Polymorphism, Mercaptopurine, Bone Marrow Suppression
2 Mar 2017
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Mercaptopurine side effects include infection symptoms, gi issues like vomiting, diarrhea, loss of appetite and easy bruising/ bleeding. These drugs have overlapping side effects especially in regards to the gi track. Stan is presenting fever, anemia, susceptible to infections, loss of appetite and unexplained bruising. It looks like mercaptopurine could be the cause but due to overlapping side effects it is dif cult to tell you should consider the pharmacokinetics. Mercaptopurine: incompletely absorbed when taken orally, metabolized in liver and excreted in urine. Mercaptopurine is a pro-drug that is metabolized to it"s active form thioguanine nucleotides (tgns). Methotrextate: hepatic and intracellular metabolism, crosses placenta and blood brain barrier poorly as it is ionized, 50% protein bound, oral doses readily absorbed high bioavailability, a long terminal half-life. Genetic variation could cause different reactions to identical treatments. If an individual has a single nucleotide polymorphism (snp) it could drastically change the drug response.
