Pharmacology 4620A Study Guide - Comprehensive Final Exam Guide - Enzyme, Cell Surface Receptor, Protein
20 Nov 2018
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Lecture 1: molecular and structural basis of drug action. Naturally present in the body but can also be made exogenously. Kept small so that it is easily digestible and disturbed to its target in the body. Can"t be admistiend orally because it will be digested. Take out and engineer the host"s t-cells to recognize cancer and reintroduced to the host. Now: used for editing the the car-t cells after it is removed from the host. Finding a target that is important in a certain disease and can be modified by a chemical compound to treat that disease. Identify a lead compound that binds to the target of interest. Start to improve the compound (change the chemical structure) Change it so that it can be administered it orally, etc. Administer the drug to a small group healthy volunteers to test safety. Administer the drug to healthy volunteers to test long term toxicology.
