Biology 2581B Study Guide - Quiz Guide: Haplotype, Sickle-Cell Disease, Restriction Enzyme

• School: Western University
• Department: Biology
• Course: Biology 2581B
• Professor: David R Smith

Document Summary

Mutations must be passed on (must be in the germ line) Forward mutation: changes the wild type to a different allele. Reverse mutation: causes mutation to revert back to wild-type (reversion) Any allele existing in a population at a relatively high frequency (>1%) Allele that dictates the most common phenotype in a population (dominant allele) Hint: tell you which gene is the wild type but its not always represented by a capital letter or a plus sing. Substitution: base is replaced by one of the other three bases. Transitions: purine to anther purine, or one pyrimidine. Deletion: block of one or more dna pairs is lost. Insertion: block of one or more dna pairs is added. Inversion: 180 degree rotation of piece of dna. Conservative mutations: similar amino acids (i. e. replace a polar aa with another polar aa) Doesn"t lead to a lot of differences in the phenotype itself. Longer gene is more likely to have mutations.