Biology 2581B Study Guide - Quiz Guide: Coiled Coil, Polymerization, Atp Hydrolysis
2 May 2020
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Antimitotic, anticancer drugs: interfere with spindle assembly, inhibit cell division useful for cancer treatments. 2 intertwined chains of f-action (g-actin) actin is the monomeric building block in microfilaments. G-actin polymerises to form f-actin 2 coiled strands of polymerised g-actin (globular to filamental) Beta and gamma actin is found in all cells. G actin polymerises into f actin filaments to form alpha helix (g-actin join ends, wrap coiled) Higher affinity for the plus ends, but depends on the atp hydrolysis. Assembly of monomeric actin into filaments depends on atp binding/hydrolysis. Due to higher affinity for + end, atp binds here and spontaneously hydrolyses adp + pi at minus end. Adp bound actin is less stable and tends to deplymerise/detach. To recycle actin monomers, adp is exchanged for atp and for + end growth. Interacts with myosin (motor protein) because of polarity. Regulation of actin is very complex and controlled. Stabilises process and increases affinity for +/growing end.
